DMPK Project Lead

RBW are working in partnership with a global organisation that are searching for an experienced DMPK Lead to implement strategy across all DMPK disciplines including PK/PD, ADME, Biotransformation etc. from early discovery through to clinical development.

Responsibilities:

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• Lead the nonclinical DMPK strategy and design the appropriate studies to fulfil regulatory requirements
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• Have an expert understanding of the different approaches related to nonclinical pharmacokinetics
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• Apply understanding of physical properties, DMPK and enzymology to contribute to the design of new compounds
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• Work with colleagues globally to resolve project-related ADME challenges
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• Author high quality regulatory documents including INDs, CTAs and NDA filings
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Experience:

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• Educated to PhD in a scientific related discipline
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• Minimum 5 years industry experience contributing to drug discovery projects with a track record of moving small molecules from target validation to first in humans
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• Strong background in the area of DMPK/ADME across discovery and development
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• Good understanding of PKPD and PBPK modelling
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• Proven skills for in-depth mechanistic understanding of DMPK-related issues and of the impact and value of translation to humans
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